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除了抑制DHT这一经典路径，全新的作用机制药物也开始从实验室走向临床，试图将脱发治疗从“抗雄”转向“促生”。其中，Wnt/β-catenin通路作为毛囊发育与生长期维持的核心通路，海外 Samumed的SM04554（小分子Wnt通路激活剂）已完成II期临床试验，可激活静止期毛囊、促进新生毛发生长，国内君实生物也已启动该靶点布局。